Kenzar Plus Drug Interactions

Losartan: No significant drug-drug pharmacokinetic interactions have been found in interaction studies with Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine and Phenobarbital.
As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g. Spironolactone, Triamterene, Amiloride), potassium supplements or salt substitutes containing potassium may lead to increase in serum potassium.
As with other antihypertensive agents, the antihypertensive effects of Losartan may be blunted by the non-steroidal inflammatory drug Indomethacin.
Hydrochlorothiazide: When administered concurrently, the following drugs may interact with thiazide diuretics: Alcohol, Barbiturates or narcotics: potentiation of orthostatic hypotension may occur.
Anti-diabetic drugs (oral agents and insulin): dosage adjustment of the antidiabetic drug may be requested.
Other antihypertensive drug: additive effect.
Skeletal muscle relaxants: possible increased responsiveness to the muscle relaxant.
NSAIDs: in some patients, it can reduce the antihypertensive effects of thiazide diuretics.